Description:Non-negative Matrix Factorization
Abstract:bioNMF is a web-based tool that implements the Non-negative Matrix Factorization (NMF) methodology in different analysis contexts to support some of the most important reported applications in biology. This tool can find cluster genes and samples that are highly related in sub-portions of the data (Biclustering analysis), determine the most suitable number of sample clusters in a given dataset (Sample Classification), or just perform the classical Lee-Seung NMF algorithm (Standard NMF). This on-line tool provides an user-friendly interface, combined with a computational efficient parallel implementation of several NMF methods (standard, divergence and non-smooth NMF). In addition to the on-line access, bioNMF also provides a public web-services interface, enabling users with more computer expertise to launch jobs into bioNMF server from their own scripts and workflows.