Software SimTriplex | EGI Applications Database

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Name:SimTriplex

Description:Immunoprevention of spontaneous tumors has been explored in recent years in preclinical systems thanks to the availability of several new transgenic mouse models that closely mimic the natural history of human tumors. The most thoroughly investigated model of cancer immunoprevention is the mammary carcinoma of HER-2\/neu transgenic mouse. A complete prevention was obtained using a combination of three signals (the so called \ triplex\ vaccine) that included the specific antigen (viz. p185, the product of HER-2\/neu) and nonspecific signals like allogeneic histocompatibility antigens and interleukin 12. The major issue still unresolved with the Triplex vaccine is whether or not the Chronic schedule is the minimal set of vaccination yielding complete, long-term protection from mammary carcinoma. In order to attack this kind of problem the SimTriplex simulator was developed. SimTriplex is based on a modification of the Celada-Seiden framework. SimTriplex mimics at the cellular level the behaviour of immune cells of vaccinated as well as naive mice. This is a generalized cellular automaton and it is specialized in modeling mammary carcinoma - Triplex vaccine - immune system competition.

Experiment: immune system prevention of mammary carcinoma and to predict the action of a vaccine against an antigenic variation
Software requirements: c standard mathematical library ^

Abstract:Immunoprevention of spontaneous tumors has been explored in recent years in preclinical systems thanks to the availability of several new transgenic mouse models that closely mimic the natural history of human tumors. The most thoroughly investigated model of cancer immunoprevention is the mammary carcinoma of HER-2\/neu transgenic mouse. A complete prevention was obtained using a combination of three signals (the so called \ triplex\ vaccine) that included the specific antigen (viz. p185, the product of HER-2\/neu) and nonspecific signals like allogeneic histocompatibility antigens and interleukin 12. The major issue still unresolved with the Triplex vaccine is whether or not the Chronic schedule is the minimal set of vaccination yielding complete, long-term protection from mammary carcinoma. In order to attack this kind of problem the SimTriplex simulator was developed. SimTriplex is based on a modification of the Celada-Seiden framework. SimTriplex mimics at the cellular level the behaviour of immune cells of vaccinated as well as naive mice. This is a generalized cellular automaton and it is specialized in modeling mammary carcinoma - Triplex vaccine - immune system competition. Experiment: immune system prevention of mammary carcinoma and to predict the action of a vaccine against an antigenic variation Software requirements: c standard mathematical library ^